Beli - The Science of Men's Prenatal and Women's Prenatal ... Cochrane Database Syst Rev kind of research in the world, the studies conducted in 2015;2:CD000230. It is necessary for proper growth and immune function. Randomised trials of zinc supplementation in pregnancy. However, micronutrient deficiency among breastfeeding mothers and their infants also remains an issue in high-income settings . In relation to mineral supplementation during pregnancy, calcium and zinc were effective to improve maternal and infant outcomes. Treatment of diarrhoeawith zinc 7. Effects of zinc supplementation during pregnancy on ... PDF Micronutrient and vitamin supplementation during pregnancy ... J. Nutr.125(8),2122-2127 (1995). Summary of this review; Related systematic reviews. 10 Mori, R, Ota, E & Middleton, P, et al. Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes. micronutrient and vitamin supplementation during pregnancy to improve certain maternal and child health outcomes, which is especially important for populations living in low- and middle-income settings. Most previous attempts to improve birthweight through multiple micronutrient supplementation have been initiated after women are pregnant. Night blindness is prevalent during pregnancy and lactation in rural Nepal. Zinc supplementation for improving pregnancy and infant ... Zinc supplementation for improving pregnancy and infant ... Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems led to 80% reduction of LBW for women receiving low-dose calcium (less than 1 g per day). (2012) Zinc supplementation for improving pregnancy and infant outcome. Maternal zinc deficiency during pregnancy elevates the ... This systematic review assesses the effect of single and multiple micronutrient supplementation during pregnancy on offspring mental development. doi: 10.1002/14651858.CD007079.pub2. Mannino F. Neonatal complications of postterm gestation. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems led to 80 per cent reduction of LBW for women receiving low-dose calcium (less than 1g per day). Search strategy: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (February 2007). Zinc supplementation for improving pregnancy and infant outcome. Ota, E. et al. CD000230) | Find, read and cite all the research you need on ResearchGate Effects of maternal zinc supplementation on pregnancy and lactation outcomes. Background Although maternal nutrient status influences all aspects of fetal development including the brain, the impact of micronutrient supplementation on the baby's mental function is a topic of debate. Maternal zinc deficiency during pregnancy has been related to adverse effects on progeny, and there are data showing that mild to moderate zinc deficiency (as assessed by available indicators) is quite common in the developing world. Zinc deficiency can cause several complications including periorificial lesions, delayed wound healing . Zinc supplementation reduces the frequency of preterm birth by 14%, decreases respiratory infections and childhood diarrhoea, lowers all-cause mortality and increases growth and weight gain among infants and young children. Deficiencies worsen during pregnancy due to increased energy and nutritional demands, causing adverse outcomes in mother and child, but could be mitigated by interventions like micronutrient supplementation. Zinc supplementation for improving pregnancy and infant outcome. Supplementation with multiple micronutrients was particularly good at improving several outcomes. Multiple micronutrient supplementation in pregnancy 2. Hess SY, King JC. In this thesis two intervention studies are described to evaluate the effect of zinc supplementation during the last six months of pregnancy or between 1 and 6 months of age in infancy on pregnancy outcome, infant growth, morbidity from infectious diseases and immune response to childhood vaccines during the first six months of life. Studies have found that nutrients like L-carnitine, Vitamins C and E, N-acetylcysteine, Zinc and CoQ10 could increase your fertility four-fold. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 September 2011) and reference lists of retrieved studies. Observational data relating zinc deficiency to adverse fetal outcome have produced conflicting results, mainly . Zinc supplementation for improving pregnancy and infant outcome Taking zinc during pregnancy helps to slightly reduce preterm births, but does not prevent other problems such as low birthweight babies. Buppasiri P, Lumbiganon P, Thinkhamrop J, et al. Whether zinc should be added to usual antenatal supplements in regions with high rates of low birthweight should be reviewed. Further research should be done to establish Mori, R. et al. Fact Sheet for Health Professionals. Cochrane Database Syst. Zinc deficiency in pregnancy has been convincingly associated with adverse fetal outcomes, but routine supplementation has not yet been shown to be effective. Zinc supplementation for improving pregnancy and infant outcome. Maternal zinc supplementation during pregnanchy resulted in a reduction of the health risks in Bangladeshi low-birthweight infants, although this intervention did not improve birthweight. The evidence that maternal zinc supplementation lowers the risk of preterm birth was graded low; evidence for a positive effect on other foetal outcomes was graded as very low. 5 two recent systematic reviews report meta-analyses of randomised controlled trials of zinc supplementation during pregnancy conducted across five … Effect of Zinc Supplementation on Early Outcome of Neonatal Sepsis - A Randomized Controlled Trial Effect of Zinc Supplementation on Early Outcome of Neonatal Sepsis - A Randomized Controlled Trial Newton, Banupriya; Bhat, Ballambattu; Dhas, Benet; Mondal, Nivedita; Gopalakrishna, Sridhar 2016-04-01 00:00:00 Zinc supplementation in neonates with sepsis improves the neurological status at one . Cochrane Database Syst Rev 2015; :CD007079. 2012;7:CD000230. Animal experiments indicate that zinc deficiency can result in adverse maternal and fetal consequences. Zinc supplementation during pregnancy and lactation plays a role in improving both maternal and foetal health. 2007;(2):CD000230. The majority of these people live in low-income settings and are typically deficient in more than one micronutrient. Cochrane Database Syst Rev 2012; :CD000230. Epub 2017 Sep 11. Milder zinc deficiency is usually acquired and is common in older people. Zinc supplementation for improving pregnancy and infant outcome. Zinc iron serum level was not found to have any relationship supplementation for improving pregnancy and with prolonged labor. There is not enough evidence that zinc supplementation during pregnancy results in improvements in maternal or neonatal outcomes. Pregnancy / Lactation. This cross-sectional study was conducted to determine the prevalence of, and factors related to, zinc deficiency in . 2000, 130 (5S Suppl): 1374S-1377S. Art. The most commonly used forms of zinc for fortification are zinc oxide and zinc sulfate and evidence suggests positive effects . Recent esti- pregnancy had zinc deficiency, while 35% of mothers mates have shown that about half a million deaths of consuming zinc supplement had deficiency during preg- mothers and children due to zinc deficiency occur annu- nancy (P < 0.001).Zinc deficiency was seen in 31 % of ne- ally worldwide, which raises widespread concerns about . This article has been updated in "Zinc supplementation for improving pregnancy and infant outcome." Cochrane Database Syst Rev. Zinc supplementation for improving pregnancy and infant outcome By Rintaro Mori, Erika Ota, Philippa Middleton, Ruoyan Tobe-Gai, Kassam Mahomed and Zulfiqar A Bhutta Cite Very preterm infants and small for gestational age infants are at risk for Zinc deficiency. Boosting sperm health, even if no fertility issues are present, can increase your chances of conceiving and sustaining a healthy pregnancy. These results indicate that interventions with zinc supplementation alone are unlikely to reduce the incidence of low birth weight in Bangladesh. Zinc supplementation for improving pregnancy and infant outcome. J Nutr. The findings of this review support the use of micronutrient and vitamin supplementation during pregnancy to improve certain maternal and child health outcomes, which is especially important for populations living in low- and middle-income settings. To assess the effects of zinc supplementation in pregnancy on maternal, fetal, neonatal and infant outcomes. Recently, maternal zinc supplementation was suggested as one possible nutritional intervention during pregnancy to improve pregnancy outcome in developing countries . Katz J, Khatry SK, West KP et al. Supplementation with multiple micronutrients was particularly good at improving several outcomes. 29 However, this . Zinc supplementation in pregnancy has been studied. Cochrane Database Syst Rev. Cochrane Database Syst Rev. By continuing to browse this site you agree to us using cookies as described in About Cookies . Zinc - The Unbiased Truth, Evidence-Based Health Benefits, How to Take & Side Effects. Google Scholar Effect of Zinc Supplementation on Pregnancy and Infant Outcomes: A Systematic Review Cochrane Database Syst Rev. Zinc supplementation for improving pregnancy and infant outcome Ota E, Mori R, Middleton P, Tobe-Gai R, Mahomed K, Miyazaki C, Bhutta ZA. 2015; Issue 2. Recognition and management of severe acute malnutrition In light of the currently available informa- life with prenatal zinc supplements, which were not contin- tion, routine zinc supplementation cannot be advocated ued after birth.40 This benefit may be due to the impact of to improve pregnancy outcome. The rapid pace of fetal development by far exceeds any other stage of the life span, and thus, environmental influences can profoundly alter the developmental course. The effect of zinc supplementation on preterm birth, if causal, might reflect a reduction in maternal infection, a primary cause of prematurity. Ota E, Mori R, Middleton P, Tobe-Gai R, Mahomed K, Miyazaki C, Bhutta ZA. The association of serum copper with ceruloplasmin and zinc with folic acid levels in recurrent pregnancy loss in Iraqi Women Olaa Riad Kadim 1, Shatha M. J. Al-Khateeb 1, Esraa H Humadi 2 1 Department of Chemistry and Biochemistry, College of Medicine, Al-Mustansiryia University, Baghdad, Iraq 2 Department of Obstetrics and Gynaecology, College of Medicine, Al-Mustansiryia University, Baghdad . These results suggest that supplementation with folate and zinc may improve semen quality and assisted reproductive technology outcomes. Everything you need to know about its function, benefit, the risk of deficiency, and potential side effects. : CD000230. Zinc supplementation for improving pregnancy and infant outcome Review Erika Ota, Rintaro Mori, Philippa Middleton, Ruoyan Tobe‐Gai, Kassam Mahomed, Celine Miyazaki, Zulfiqar A Bhutta 2015;(2):CD000230. Krebs NF: Overview of zinc absorption and excretion in the human gastrointestinal tract. Stress during the prenatal period, including malnutrition and inflammation, impact maternal and fetal neurodevelopment with long-term consequences for physical and mental health of both the mother and her child. 2 , CD000230 (2015). Abstract Background: It has been suggested that low serum zinc levels may be associated with suboptimal outcomes of pregnancy, such as prolonged labour, atonic postpartum haemorrhage, pregnancy-induced hypertension, preterm labour and post-term pregnancies, although these associations have not yet been established. Design Overview of systematic reviews (SRs). Delayed wound healing, impaired taste, loss of appetite, hair loss, fertility issues,. Objectives Background and Objectives: Zinc is a micronutrient that plays an important role in metabolism, cell growth regulation, and differentiation. in view of the possible benefits of zinc supplementation for reducing the risk of premature delivery, the possible positive impact of zinc supplementation on infant birthweight among undernourished women, and the lack of reported adverse effects, zinc should be included in maternal supplements given during pregnancy in populations at risk for … This is an update of "Zinc supplementation in pregnancy. But, other animal foods are also excellent sources of zinc. Future research to address ways of improving the overall nutritional status of pregnant women, particularly in low-income regions, and not looking at zinc in isolation, should be an urgent priority. No. Read more about Anderson (2013) Effect of iodine supplementation in pregnancy on child development and. Cochrane Database Syst Rev. 2021 Mar 16;3:CD000230. A Cochrane review found a slight reduction in incidence of preterm births, but no effect on low birth weight.71 No differences were found for maternal or other neonatal outcomes. Indian J Pediatr. 2018 Jan;85(1):5-9. doi: 10.1007/s12098-017-2444-8. It has been suggested that low serum zinc levels may be associated with suboptimal outcomes of pregnancy such as prolonged labour, atonic postpartum haemorrhage, pregnancy-induced hypertension, preterm labour and post-term pregnancies, although many of these associations have not yet been established. Mori R, Ota E, Middleton P, et al. J Reprod Med 1988; 33:271. Google Scholar This is an update of "Zinc supplementation in pregnancy." Cochrane Database Syst Rev. Request PDF | On Jul 1, 2006, K. Mahomed published Zinc supplementation in pregnancy (Withdrawn Paper. Vitamin A supplementation 5. Due to the varying doses of zinc supplementation, we were unable to determine the ideal dose-response relationship between zinc supplementation and feto-maternal outcomes, however, World Health Organization (WHO) and International Zinc Nutrition Consultative Group provided the gestational zinc requirement of 2.27 (mg/day) and 2.68 (mg/day . Although there is a dearth of this infant outcome. 5, pp. Cochrane Database Syst Rev. Effects of zinc supplementation during pregnancy on pregnancy outcome in women with history of preterm delivery: A double-blind randomized, placebo-controlled trial. Four groups were supplemented for 12 weeks: (1) weekly iron and folic acid (IFA); (2) weekly IFA and 30 mg zinc; (3) daily IFA; (4) daily IFA and 15 mg zinc. National Institutes of Health. Zinc is an essential mineral that is found in almost every cell of the body. The Cochrane Database Systematic Reviews, issue 7: CD000230 . Zinc supplementation versus no zinc (with or without placebo) for improving pregnancy and infant outcome. Mori R, Ota E, Middleton P, Tobe-Gai R, Mahomed K, Bhutta ZA: Zinc supplementation for improving pregnancy and infant outcome. Future studies should collect data on outcomes beyond micronutrient concentrations, for example: maternal and infant morbidity, adverse effects, maternal satisfaction, the risks of excess supplementation, and potential adverse interactions between the micronutrients and the other outcomes. Zinc supplementation for improving pregnancy and infant outcome. To our knowledge, this is the first systematic . Almost two billion people are deficient in key vitamins and minerals, mostly women and children in low- and middle-income countries (LMICs). Severe zinc deficiency is rare and usually congenital. Data sources Searches conducted in January 2019: Ovid Medline (1946-), Cochrane Library databases. Google Scholar 50. 2015 Feb 2;2:CD000230. Selection criteria: Randomised or quasi-randomised trials of zinc supplementation in pregnancy. In the present study, zinc supplementation in neonatal sepsis improved the neurological status at one month of age [p = 0.02, RR (95%CI) = 0.28 (0.11-0.73)]. This article has been updated in "Zinc supplementation for improving pregnancy and infant outcome." Cochrane Database Syst Rev. We aim to systematically review and meta-analyze randomized controlled trials evaluating effects of preventive zinc supplementation for 3 months or longer during pregnancy or in children up to age 5 years on pregnancy outcomes and child growth; (2) Methods: We . Taking zinc during pregnancy helps to slightly reduce preterm births, but does not prevent other problems such as low birthweight babies. Rev.2,CD000230 (2007). Zinc supplementation for improving pregnancy and infant outcome (Review) There is strong evidence primarily from developed countries that zinc, calcium and magnesium supplementation could improve birth weight, prematurity and hypertension particularly in high risk groups and there is a need for well designed RCT's that will examine the role of selected nutrient interactions and multi vitamin-mineral supplements in improving pregnancy outcomes. Observational data relating zinc deficiency to adverse fetal outcome have produced conflicting results, mainly because of the lack of a valid indicator of zinc deficiency in pregnancy. 403-408. . BACKGROUND: Globally, more than two billion people are estimated to be deficient in key vitamins and minerals, particularly iodine, iron and zinc. Zinc supplementation for improving pregnancy and infant outcome The evidence for a 14% relative reduction in preterm birth for zinc compared with placebo was primarily represented by trials involving women of low income and this has some relevance in areas of high perinatal mortality. While dietary supplements marketed for male fertility commonly contain folic acid and zinc based on limited prior evidence for improving semen quality, no large-scale trial has examined the efficacy of this . This is an update of "Zinc supplementation for improving pregnancy and infant outcome." Cochrane Database Syst Rev. The Journal of Maternal-Fetal & Neonatal Medicine: Vol. Based on the various observations and discussions made, it is evident that majority of the studies favored zinc supplementation for improving the survival rate and neurological outcome. Promotion of appropriate complementary feeding 4. Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes. Background: It has been suggested that low serum zinc levels may be associated with suboptimal outcomes of pregnancy such as prolonged labour, atonic postpartum haemorrhage, pregnancy-induced hypertension, preterm labour and post-term pregnancies, although many of these associations have not yet been established. The beneficial effects of single-nutrient supplementation including magnesium , zinc , calcium and its co-administration with vitamin D on attenuating inflammation and oxidative stress, and improving pregnancy outcomes have been proved in women with GDM. Ota E, Mori R, Middleton P, Tobe‐Gai R, Mahomed K, Miyazaki C, et al. In relation to mineral supplementation during pregnancy, calcium and zinc were effective to improve maternal and infant outcomes. Outcome group: Child dev. Zinc supplementation for improving pregnancy and infant outcome. The daily food of Vietnamese people is mainly rice, which contains very little zinc. tant predictor of infant birthweight. Short Term Oral Zinc Supplementation among Babies with Neonatal Sepsis for Reducing Mortality and Improving Outcome - A Double-Blind Randomized Controlled Trial. Vietnam has many population groups living in poverty. [DOI: 10.1002/14651858.CD000230.pub5] [PMC free article] [Google Scholar] Studies of human pregnancy and zinc supplementation, including those from developing countries, have failed to document a consistent beneficial effect on fetal . Interventions to improve maternal nutritional status prior to conception may be more effec - tive in preventing low birthweight and improving other infant health outcomes. The lack of a valid indicator precludes a true estimate of zinc deficiency in pregnancy in various populations. Buppasiri P, Lumbiganon P, Thinkhamrop J, Ngamjarus C, Laopaiboon M. Buppasiri P, et al. studies of the effects of zinc supplementation during pregnancy have shown inconsistent results, possibly in part because of the challenges in establishing baseline zinc status in populations. (2010). However, it is possible that mild to moderate deficiency (as assessed by available indicators) may be common in the developing world. Mahomed K, Bhutta Z, Middleton P. Zinc supplementation for improving pregnancy and infant outcome. Promotion of breastfeeding 3. In relation to mineral supplementation during pregnancy, calcium and zinc were effective in improving maternal and infant outcomes. Methods Eleven electronic literature . We investigated interactive effects of combined zinc and iron supplementation in a randomized controlled trial conducted in 459 Guatemalan women. Our site uses cookies to improve your experience. Cochrane Database Syst. You can find out more about our use of cookies in About Cookies, including instructions on how to turn off cookies if you wish to do so. The reviewers favor addressing overall nutritional status rather than focusing only on . The results of cross-sectional studies suggest that low dietary zinc intake or low maternal plasma zinc are associated with an increased risk of LBW and preterm delivery ( 7 - 9 ). Cochrane Database of Systematic Reviews. 2012, 7: CD000230. Cochrane Database of Systematic Reviews 2015, Issue 2. Eligibility criteria for selecting studies Two reviewers independently screened . Objectives: To assess the effects of zinc supplementation in pregnancy on maternal, fetal, neonatal and infant outcomes. Zinc. doi: 10.1002/14651858.CD000230.pub5. Shawn K. Baker (2009) Preventive Zinc Supplementation Among Infants, Preschoolers, and Older Prepubertal Children. 2000;(2):CD000230. Zinc supplementation for improving pregnancy and infant outcome. Zinc supplementation in children improves mean serum zinc concentration, improves height, reduces diarrhea morbidity, and leads to a small reduction in all-cause childhood mortality with no significant adverse effects. Since zinc is not stored in or manufactured by the body, it must be ingested in proper amounts each day. Iron and zinc may interact in micronutrient supplements and thereby decrease efficacy. Oysters are well known for their zinc content. Population: Normal pregnant women with no systemic illness Settings: Bangladesh, Chile, China, Denmark, Egypt, Ghana, Indonesia, Iran, Nepal, Pakistan, Peru, South Africa, UK, USA Intervention: Zinc supplementation versus no zinc (with or without placebo) Rev. 2011 Oct 5;(10):CD007079. Objective To review the evidence to assess effectiveness of vitamin D supplementation during pregnancy and associations of serum vitamin D levels with perinatal outcomes. Many women of childbearing age may have mild to moderate zinc deficiency. Conclusions: Supplementation with 30 mg elemental Zn during the last 2 trimesters of pregnancy did not improve birth outcome in Bangladeshi urban poor. Google Scholar 1. However, to our best knowledge the effects of multinutrients supplementation (magnesium . Preventive zinc supplementation 6. We excluded quasi-randomised controlled trials. Maternal undernutrition affects a large proportion of women in many developing countries, but has received little attention as an important determinant of poor maternal, newborn, and child health (MNCH) outcomes such as intrauterine growth restriction, preterm birth (PTB), and maternal and infant morbidity and mortality. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems led to 80% reduction of LBW for women receiving low-dose calcium (less than 1 g per day). Vorherr H. Placental insufficiency in relation to postterm pregnancy and fetal postmaturity. Calcium. . 23, No. Zinc and its vital roles in your body for health. Middleton P. BACKGROUND: It has been suggested that low serum zinc levels may be associated with suboptimal outcomes of pregnancy such as prolonged labour, atonic postpartum haemorrhage, pregnancy-induced hypertension, preterm labour and post-term pregnancies, although many of . Request PDF | On Feb 1, 2015, Ota E and others published Zinc supplementation for improving pregnancy and infant outcome | Find, read and cite all the research you need on ResearchGate One primary . 7, CD000230 (2012). Banupriya N, Bhat BV, Benet BD, Catherine C, Sridhar MG, Parija SC. Manifestations of zinc deficiency may be subtle and can affect many organ systems. 29 However, this . . zinc supplementation on the ontogeny of immunologic development in the infant during the first . Read more about Shawn K. Baker . 2006, art no. Previously, vitamin A supplementation in ∼20 000 pregnant women failed to show an effect on fetal loss or early infant mortality in Nepal,6 although in a subgroup of night-blind (ie, vitamin-A-deficient) women there was an increased risk of infant mortality.7 The evidence with regard to the relationship between prenatal zinc supplementation . (1) Background: The effects of zinc supplementation on child growth, and prior reviews of these studies, have shown mixed results. Of combined zinc and its vital roles in your body for health study was to. '' > effect of iodine supplementation in a randomized Controlled trial may be subtle and can affect many organ.. Necessary for proper growth and immune function moderate deficiency ( as assessed by available indicators may. Are pregnant 2018 Jan ; 85 ( 1 ):5-9. doi:.. 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